Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more?in print and online at expertconsult.com.

Sect. A General Concepts 1
1 Epidemiology of Allergic Diseases 1
2 Natural History of Allergic Diseases and Asthma 10
3 The Genetics of Allergic Disease and Asthma 23
4 Regulation and Biology of Immunoglobulin E 39
5 Inflammatory Effector Cells/Cell Migration 51
6 The Developing Immune System and Allergy 69

Sect. B Immunologic Diseases 81
7 Approach to the Child with Recurrent Infections 81
8 Antibody Deficiency 88
9 T Cell Immunodeficiencies 99
10 Pediatric Human Immunodeficiency Virus Infection 110
11 Complement Deficiencies 118
12 White Blood Cell Defects 130
13 Rheumatic Diseases of Childhood: Therapeutic Principles 145
14 Autoimmune Diseases 159
15 Autoimmune Lymphoproliferative Syndrome 170
16 Epstein-Barr Virus Infections 176

Sect. C Immune-Directed Therapies 183
17 Intravenous Immune Serum Globulin Therapy 183
18 Bone Marrow Transplantation 193
19 Immunizations 204
20 Gene Therapy and Allergy 211
21 Stem Cell Therapeutics: An Overview 224

Sect. D Diagnosis and Treatment of Allergic Disease 233
22 Laboratory (In Vitro) Analyses 233
23 In Vivo Testing for Immunoglobulin E-Mediated Sensitivity 243
24 Outdoor Allergens 252
25 Indoor Allergens 261
26 Environmental Control 269
27 Immunotherapy for Allergic Disease 277

Sect. E Upper Airway Disease 287
28 Allergic Rhinitis 287
29 Otitis Media 298
30 Sinusitis 309
31 Chronic Cough 321

Sect. F Asthma 337
32 Immunology of the Asthmatic Response 337
33 Guidelines for Treatment of Asthma 350
34 Functional Assessment of Asthma 357
35 Infections and Asthma 366
36 Special Considerations for Infants and Young Children 379
37 Inner City Asthma 392
38 Asthma in Older Children 405
39 Asthma Education Programs for Children 425
40 Asthma and the Athlete 435
41 Refractory Childhood Asthma: New Insight into the Pathogenesis, Diagnosis, and Management 444
42 Promoting Adherence and Effective Self-Management in Patients with Asthma 457
43 New Directions in Asthma Management 465

Sect. G Food Allergy 473
44 Mucosal Immunity: An Overview 473
45 Evaluation of Food Allergy 478
46 Approach to Feeding Problems in the Infant and Young Child 488
47 Prevention and Natural History of Food Allergy 495
48 Enterocolitis, Proctocolitis, and Enteropathy 510
49 Eosinophilic Esophagitis, Gastroenteritis, and Proctocolitis 518
50 Food Allergy, Respiratory Disease, and Anaphylaxis 529
51 Atopic Dermatitis and Food Hypersensitivity 538
52 Management of Food Allergy 546

Sect. H Allergic Skin and Eye Diseases 561
53 Atopic Dermatitis 561
54 Urticaria and Angioedema 574
55 Contact Dermatitis 584
56 Allergic and Immunologic Eye Disease 595

Sect. I Drug Allergy and Anaphylaxis 611
57 Drug Allergy 611
58 Latex Allergy 624
59 Insect Sting Anaphylaxis 633
60 General Treatment of Anaphylaxis 643

App. I Clinical Immunology Laboratory Values 655
App. II Food Allergy 657
Index 667