Written by the foremost experts, this text is a comprehensive clinical reference on osteoarthritis. Chapters review current information on the epidemiology, etiopathogenesis, and pathology of osteoarthritis, the biochemistry and molecular and cell biology of articular cartilage, and experimental models of osteoarthritis. Major sections focus on clinical presentations, roentgenologic and laboratory diagnosis, and treatment, including pharmacologic treatment, intra-articular therapy, surgery, arthroscopy, and complementary and alternative medicine. The authors discuss the indications, outcomes, and complications of various orthopaedic procedures. Chapters present orthopaedic approaches to osteoarthritis of various joints--the shoulder, hand, wrist, elbow, hip, knee, foot, ankle, and cervical, thoracic, and lumbar spine.

Foreword     vii
Preface     ix
Contributors     xi
Acknowledgments     xv

Basic Considerations     1
Epidemiology of Osteoarthritis   Leena Sharma   Dipali Kapoor     3
Etiopathogenesis of Osteoarthritis   A. Robin Poole   Farshid Guilak   Steven B. Abramson     27
Pathology of Osteoarthritis   Aubrey J. Hough, Jr.     51
Cell Biology, Biochemistry, and Molecular Biology of Articular Cartilage in Osteoarthritis   Linda J. Sandell   Dick Heinegard   Thomas M. Hering     73
Experimental Models of Osteoarthritis   Margaret M. Smith   Christopher B. Little     107
Molecular Genetics of Osteoarthritis   John Loughlin   Kay Chapman     127
General Aspects of Diagnosis     137
Osteoarthritis: Clinical Presentations   Michele M. Hooper   Roland W. Moskowitz     139
Radiologic Diagnosis   Garry Gold   Vijay Chandnani   Donald Resnick     147
Magnetic Resonance Imaging   Charles G. Peterfy   Julie C. DiCarlo   Manish Kothari     167
Ultrasound and Alternative ImagingOutcomes   Helen I. Keen   Paul Emery   Philip G. Conaghan     193
Laboratory Findings in Osteoarthritis   Roy D. Altman     201
Noninvasive Biochemical Markers in Osteoarthritis   Patrick Garnero     215
Secondary Osteoarthritis   H. Ralph Schumacher, Jr.   Lan X. Chen   Joseph Buckwalter     233
General Aspects of Management     255
Baseline Program   Todd Stitik   Marc C. Hochberg     257
The Pharmacologic Treatment of Osteoarthritis   Lee S. Simon   Vibeke Strand     267
Intra-Articular Therapy   David H. Neustadt   Roy D. Altman     287
Complementary and Alternative Medicine   Sharon L. Kolasinski     303
Study Design and Outcome Measures in Osteoarthritis Clinical Trials   Vibeke Strand   Marc C. Hochberg     313
Surgical Considerations in Osteoarthritis     327
General Considerations, Indications, and Outcomes   Victor M. Goldberg     329
Upper Extremity Considerations: Osteoarthritis of the Shoulder   Sara L. Edwards   John-Erik Bell   William N. Levine   Louis U. Bigliani     339
Upper Extremity Considerations: Hand, Wrist, and Elbow   Roderick J. Bruno   Jason M. McKean   Steven H. Goldberg   Robert J. Strauch   Melvin P. Rosenwasser     349
Lower Extremity Considerations: Hip   Michael N. Kang   Daniel J. Berry   William J. Maloney III     375
Lower Extremity Considerations: Knee   Brian J. Cole   Richard Berger   Victor M. Goldberg   Aaron Rosenberg     395
Lower Extremity Considerations: Foot and Ankle   James Michelson     415
Osteoarthritis of the Spine   Sanford E. Emery   Vytautas M. Ringus     427
New Frontiers in Surgery of Osteoarthritis   Tom Minas   Andreas H. Gomoll     453

Index     461