The pre-eminent reference on coagulation disorders is now in its thoroughly updated Fifth Edition. Written by more than 160 of the world's foremost authorities, this encyclopedic volume integrates basic science and clinical practice and details all that is currently known about blood clotting disorders and how to manage patients with these and related problems. This edition has been reorganized into smaller, more tightly focused chapters to help readers find information easily. A new co-editor, Samuel Z. Goldhaber, MD, has expanded the cardiology portion of the book. Other new features include a two-color page design and more than 100 full-color illustrations.

Overview of hemostasis 3
Overview of coagulation, fibrinolysis, and their regulation 17
The blood coagulation factors : their complementary DNAs, genes, and expression 21
Genetics of coagulation 59
Tissue factor structure and function 91
Contact activation (Kallikrein-Kinin) pathway : multiple physiologic and pathophysiologic activities 107
Molecular and structural biology of factor IX 131
Factor VIII and hemophilia A 151
Factor V 177
Thrombin 193
Protein Z and protein Z-dependent protease inhibitor 215
Factor XI 221
Antithrombin III and heparin cofactor II 235
Protein C, protein S, and thrombomodulin 249
Heparin and vascular proteoglycans 271
Fibrinogen structure and physiology 285
Factor XIII and fibrin stabilization 317
Plasminogen - plasmin system 335
Plasminogen activator inhibitor-1 365
Thrombin-activatable fibrinolysis inhibitor aka procarboxypeptidase U 381
[alpha]-Macroglobulins and kunins 395
Human endothelial cell plasmin-generating system 409
Physiologic regulation of fibrinolysis 419
Overview of platelet structure and function 437
Platelet production : cellular and molecular regulation 443
Platelets : structure related to function 463
Thrombopoietin 483
Platelet glycoprotein polymorphisms and relationship to function, immunogenicity, and disease 493
Molecular mechanisms of drug-induced thrombocytopenia 507
Integrin [alpha][subscript IIb][beta][subscript 3] and platelet aggregation 517
The platelet glycoprotein Ib/IX/V complex and platelet adhesion 531
Platelet adenosine 5'-diphosphate receptors 547
Protease-activated receptors in hemostasis, thrombosis, and vascular biology 555
Platelet - collagen receptors 567
Platelet prostanoid receptors 575
Platelet eicosanoids 583
Platelet and megakaryocyte lipids 591
Role of platelets in blood coagulation 605
Platelet signal transduction 617
Overview of vascular biology, embryogenesis, development, and disorders 631
Development of the vascular system 633
The vascular biology of nitric oxide and nitric oxide synthases 653
Vascular adaptations to altered blood flow 667
Angiogenesis, lymphangiogenesis, and vascular morphogenesis 679
Monocyte-platelet-endothelial interactions 691
Structure and function of von willebrand factor 707
Platelet-vessel wall interactions in flowing blood 723
Rheology of thrombosis 737
Biomaterial-associated thrombosis 751
The vascular response to injury 761
Vessel wall lipids 769
Thrombophilia genetics 779
Inflammation and atherothrombosis 795
Histopathology of atherosclerosis 813
Laboratory markers of platelet activation 825
Laboratory markers of coagulation and fibrinolysis 835
Malignancy and hemostasis 851
Overview of inherited hemorrhagic disorders 877
Clinical manifestations and therapy of the hemophilias 887
von Willebrand disease : diagnosis, classification, and treatment 905
Inherited disorders of prothrombin conversion 923
Afibrinogenemias and dysfibrinogenemias 939
Familial multiple coagulation factor deficiencies 953
Hereditary disorders of platelet secretion and signal transduction 961
Inherited thrombocytopenias 975
Inherited abnormalities of the platelet membrane : Glanzmann Thrombasthenia, Bernard-Soulier syndrome, and other disorders 987
Primary vascular disorders 1011
Hemostatic abnormalities in liver disease 1025
Clinical disorders of fibrinolysis 1035
Acquired qualitative platelet defects 1045
Acquired disorders of coagulation : the immune coagulopathies 1061
Immune thrombocytopenic purpura 1085
Drug-induced thrombocytopenia 1095
Hemostatic problems in surgical patients 1103
Obstetric hemorrhage 1121
Clinical approach to the bleeding patient 1147
Management of acute hemorrhage 1159
Therapy with antifibrinolytic agents 1173
Transfusion medicine platelet transfusion therapy, plasma, and plasma concentrates 1193
New approaches for the therapy of bleeding disorders, including gene therapy 1205
Overview of venous thromboembolism 1219
Epidemiology of venous thromboembolism 1227
Women's health and venous thromboembolism 1235
Cancer and thrombosis 1251
Venous thrombosis in unusual sites 1263
Pt. I Upper extremity deep vein thrombosis
Pt. II Cranial and Abdominal Venous Thrombosis
Diagnosis of venous thromboembolism 1279
Risk stratification in patients with pulmonary embolism 1299
Treatment of venous thromboembolism 1307
Thrombolysis in venous thromboembolic disease 1317
Mechanical devices and embolectomy 1331
Chronic thromboembolic pulmonary hypertension 1339
Paradoxical embolism 1351
Prevention of venous thromboembolism in general surgery 1361
Prevention of venous thromboembolism in orthopedic surgery 1369
Venous thromboprophylaxis in medical patients 1381
Acute coronary syndromes 1387
Antithrombotic therapy for percutaneous coronary intervention 1405
Coronary bypass grafting and cardiac surgery 1433
Medical therapy for peripheral arterial disease 1441
Surgery for peripheral arterial disease 1453
Prevention and treatment of acute stroke 1477
Interdisciplinary management of acute stroke 1497
Antithrombotic therapy for patients with atrial fibrillation 1517
Advanced cardiomyopathy and surgery 1529
Valvular heart disease 1539
Overview of complex thrombohemorrhagic disorders 1553
Myeloproliferative disorders and thrombohemorrhagic complications 1557
Consumptive thrombohemorrhagic disorders 1571
Coagulation abnormalities in sepsis 1601
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome 1613
Antiphospholipid antibodies and the antiphospholipid syndrome 1621
Thrombosis in infancy and childhood 1637
Heparin-induced thrombocytopenia 1649
Coumarin-induced skin necrosis and venous limb gangrene 1663
Anticoagulant therapy for major arterial and venous thromboembolism 1673
Anticoagulation clinics 1689
Drug interactions with oral anticoagulants 1699
Hemorrhagic complications of anticoagulation 1707
Antiplatelet therapy 1725
Foundations of thrombolytic therapy 1739
New thrombolytic agents 1753
New antithrombotic drugs 1763