Prepared by residents and fellows and reviewed by clinical faculty at the Washington University School of Medicine, this handbook is a practical quick-reference guide to the diagnosis and treatment of hematologic disorders and adult malignancies. It covers both inpatient and outpatient management approaches with the same front-lines practicality as the world-famous Washington Manual(R) of Medical Therapeutics. This thoroughly updated Second Edition includes new standards in the treatment of malignancies, mechanisms of action of new therapeutic agents, and the current use of molecular prognostic factors. Key points about diagnosis and management of disorders are bulleted for easy reference. This edition also includes illustrations. The Washington Manual(R) is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by LWW under license from Washington University.

Contributing Authors     vi
Chairman's Note     ix
Preface     x
Hematology
Introduction and Approach to Hematology   Pablo Ramirez     1
White Blood Cell Disorders: Leukopenia and Leukocytosis   Mark A. Schroeder     11
Red Blood Cell Disorders   Walter W. Chan   Jinny E. Chang     23
Platelets: Thrombocytopenia and Thrombocytosis   Sakib K. Khalid   Chanda Ho     36
Introduction to Coagulation and Laboratory Evaluation of Coagulation   Anna Margret Halldorsdottir     49
Thrombotic Disease   Meagan A. Jacoby   Nathan Martin     58
Coagulopathy   Lee Demertzis     71
Myelodysplasia, Bone Marrow Failure Syndromes, and Other Causes of Pancytopenia   Giridharan Ramsingh   Robert Schwartz     78
Myeloproliferative Disorders   John S. Welch   Mike G. Martin     90
Transfusion Medicine   James C. Mosley, III     103
Sickle Cell Disease   Meagan A. Jacoby     112
Drugs That Affect Hemostasis: Anticoagulants, Thrombolytics, and Antifibrinolytics   Nasreen Ilias   Mohsen Nasir     125
Plasma Cell Disorders   Philip E. Lammers   Tanya M. Wildes     142
Oncology
Introduction and Approach to Oncology   Prapti Patel   Tanya M. Wildes     149
Cancer Biology   Priya K. Gopalan     159
Chemotherapy   Kristan M. Augustin   Lindsay M. Hladnik     167
Introduction to Radiation Oncology   Parag J. Parikh   Imran Zoberi     183
Breast Cancer   Caron Rigden   Mariana Chavez-MacGregor     189
Lung Cancer   Janakiraman Subramanian   Vamsidhar Velcheti     204
Colorectal Cancer   Coy Heldermon     213
Other Gastrointestinal Malignancies   David Kuperman     222
Malignant Melanoma   Mike G. Martin     233
Head and Neck Cancer   Yee Hong Chia   David Kuperman     237
Sarcoma   Saiama Waqar   David Kuperman     248
Endocrine Malignancies   Mark A. Schroeder     259
Urological Malignancies   Bryan A. Faller   James C. Mosley, III     276
Gynecologic Oncology   Andrea R. Hagemann   Israel Zighelboim     287
Intracranial Tumors   Coy Heldermon     299
Leukemias   Mike G. Martin   John S. Welch     308
Lymphoma   Todd A. Fehniger     323
Introduction to Hematopoietic Stem Cell Transplantation   Pablo Ramirez     337
Human Immunodeficiency Virus-Related Malignancies   Giridharan Ramsingh   Nina Asrani     344
Cancer of Unknown Primary Site   Lukas D. Wartman     349
Supportive Care in Oncology   Brian A. Van Tine     355
Oncologic Emergencies   Lukas D. Wartman     370
Index     381