This book encompasses a broad range of concepts relating to the evolution, acquisition, development, and detection of antimicrobial resistance. There is a unique focus on the nature of antimicrobial resistance from multiple perspectives that emphasize the influence of the environment on the ecology of genes and phenotypic characteristics.
Foreword
Preface
Contributors
A Historical Introduction
1
The Ecology of Antibiotic Resistance Genes
1
2
Antibiotic Resistance: How Bacterial Populations Respond to a Simple Evolutionary Force
19
3
Global Response Systems That Cause Resistance
37
4
Drug Efflux
61
5
Mechanisms of Aminoglycoside Antibiotic Resistance
91
6
[beta]-Lactamases and Resistance to [beta]-Lactam Antibiotics
123
7
Target Modification as a Mechanisms of Antimicrobial Resistance
161
8
Antibiotic Permeability
193
9
Phenotypic Tolerance of Bacteria
209
10
Resistance as a Worldwide Problem
223
11
Genetic Methods for Detecting Bacterial Resistance Genes
239
12
Evolution and Epidemiology of Antibiotic-Resistant Pneumococci
265
13
Resistance Problems Associated with the Enterococcus
295
14
Methicillin Resistance in Staphylococcus aureus
331
15
Drug Resistance and Tuberculosis Chemotherapy - From Concept to Genomics
355
16
Antibiotic Resistance in Enterobacteria
405
17
Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings
427
18
Approaches to New Antimicrobial Targets in the Age of Genomics