The definitive haematology textbook of choice for medical students.

Hoffbrand’s Essential Haematology has built a reputation as the flagship haematology textbook for both students and junior doctors, providing an authoritative introduction to the subject.

Now in its 7th edition, this classic text provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, treatment of blood and bone marrow disorders, in its concise and user-friendly style.

Hoffbrand’s Essential Haematology outlines the basic principles of clinical and laboratory haematology and shows how manifestations of blood diseases can be explained by new knowledge of the disease processes. It is an indispensable resource for students and trainees and an essential read for all specialists who are interested in updating their knowledge.

Hoffbrand’s Essential Haematology:

• Provides up-to-date knowledge of the pathogenesis, clinical and laboratory features and treatment of all blood disorders

• Features detailed information on the new genetics of leukaemia and lymphoma

• Includes a new chapter on thrombosis, focussing on the new oral anticoagulants

• Is beautifully presented, with over 300 colour illustrations

• Comprehensively covers both theory and treatment regimes

• Includes a companion website at www.wileyessential.com/haematology featuring all the figures and tables from the book, and over 300 interactive multiple choice questions

Preface to the Seventh Edition vi

Preface to the First Edition vii

How to use your textbook viii

About the companion website x

1 Haemopoiesis 1

2 Erythropoiesis and general aspects of anaemia 11

3 Hypochromic anaemias 27

4 Iron overload 41

5 Megaloblastic anaemias and other macrocytic anaemias 48

6 Haemolytic anaemias 60

7 Genetic disorders of haemoglobin 72

8 The white cells 1: granulocytes, monocytes and their benign disorders 87

9 The white cells 2: lymphocytes and their benign disorders 102

10 The spleen 116

11 The aetiology and genetics of haematological malignancies 122

12 Management of haematological malignancy 135

13 Acute myeloid leukaemia 145

14 Chronic myeloid leukaemia 156

15 Myeloproliferative disease 165

16 Myelodysplasia 177

17 Acute lymphoblastic leukaemia 186

18 The chronic lymphoid leukaemias 197

19 Hodgkin lymphoma 205

20 Non-Hodgkin lymphoma 213

21 Multiple myeloma and related disorders 228

22 Aplastic anaemia and bone marrow failure 242

23 Stem cell transplantation 250

24 Platelets, blood coagulation and haemostasis 264

25 Bleeding disorders caused by vascular and platelet abnormalities 278

26 Coagulation disorders 290

27 Thrombosis 1: pathogenesis and diagnosis 302

28 Thombosis 2: treatment 311

29 Haematological changes in systemic disease 321

30 Blood transfusion 333

31 Pregnancy and neonatal haematology 346

Appendix: World Health Organization classification of tumours of the haematopoietic and lymphoid tissues 352

Index 357