First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Plus, a new organization and new full-color images make diagnosis easier and more efficient, and full-text online access at www.expertconsult.com allows you to rapidly search this indispensable reference from any computer.

• Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke.

• Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.

• Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides.

• Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.

• Search the complete text online at www.expertconsult.com to quickly find the answers you need, download images, and follow links to PubMed abstracts for most references.

Combat the increasing prevalence of stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leading authority Dr. Mohr.

Sect. I Epidemiology and prevention 1
Ch. 1 Distribution of stroke : heterogeneity of stroke by age, race, and sex 3
Ch. 2 Epidemiology of stroke 13
Ch. 3 Outcome following stroke 35
Sect. II Clinical manifestations 59
Ch. 4 Classification of ischemic stroke 61
Ch. 5 Internal carotid artery disease 75
Ch. 6 Anterior cerebral artery disease 101
Ch. 7 Middle cerebral artery disease 123
Ch. 8 Posterior cerebral artery disease 167
Ch. 9 Anterior choroidal artery territory infarcts 193
Ch. 10 Vertebrobasilar disease 207
Ch. 11 Lacunes 275
Ch. 12 Cerebral venous thrombosis 301
Ch. 13 Intracerebral hemorrhage 327
Ch. 14 Aneurysmal subarachnoid hemorrhage 377
Ch. 15 Arteriovenous malformations and other vascular anomalies 397
Ch. 16 Spinal cord ischemia 423
Sect. III Diagnostic studies 437
Ch. 17 Overview of laboratory studies 439
Ch. 18 Computed tomography - based evaluation of cerebrovascular disease 449
Ch. 19 Magnetic resonance imaging 461
Ch. 20 Cerebral angiography 481
Ch. 21 Ultrasonography 497
Ch. 22 Single-photon emission computed tomography 525
Sect. IV Specific medical diseases and stroke 547
Ch. 23 Artertial dissections 549
Ch. 24 Collagen vascular and infectious diseases 575
Ch. 25 Moyamoya disease 603
Ch. 26 Cervicocephalic fibromuscular dysplasia 619
Ch. 27 Migraine and stroke 629
Ch. 28 Hypertensive encephalopathy 641
Ch. 29 Vascular cognitive impairment and dementia 648
Ch. 30 Atherosclerotic disease of the proximal aorta 661
Ch. 31 Binswanger's disease and vascular dementia 679
Ch. 32 CADASIL : cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 687
Ch. 33 Cerebral amyloid angiopathy 693
Ch. 34 Coagulation abnormalities in stroke 707
Ch. 35 Stroke and substance abuse 725
Ch. 36 Cardiac diseases 747
Sect. V Pathophysiology 761
Ch. 37 Vascular biology and atherosclerosis of cerebral arteries 763
Ch. 38 The cerebral microvasculature and responses to ischemia 775
Ch. 39 Mechanisms of thrombosis and thrombolysis 785
Ch. 40 Cerebral blood flow and metabolism in cerebrovascular disease 799
Ch. 41 Histopathology of cerebral ischemia 821
Ch. 42 Molecular and cellular mechanisms of ischemia-induced neuronal death 829
Ch. 43 Apoptosis in cerebral ischemia 855
Ch. 44 Molecular pathophysiology of white matter anoxic-ischemic injury 867
Ch. 45 Cerebral ischemia and inflammation 883
Ch. 46 Intracellular signaling : mediators and protective responses 895
Sect. VI Therapy 903
Ch. 47 Prehospital and emergency department care of the patient with acute stroke 905
Ch. 48 Intravenous thrombolysis 919
Ch. 49 Intra-arterial thrombolysis in acute ischemic stroke 943
Ch. 50 Antithrombotic therapy for acute ischemic stroke 953
Ch. 51 General stroke management and stroke units 971
Ch. 52 Critical care of the patient with acute stroke 987
Ch. 53 Pharmacologic modification of acute cerebral ischemia 1025
Ch. 54 Treatment of "other" causes of stroke 1059
Ch. 55 Medical therapy of intracerebral and intraventricular hemorrhage 1079
Ch. 56 Rehabilitation and recovery of the patient with stroke 1089
Ch. 57 Antiplatelet therapy for secondary prevention of stroke 1107
Ch. 58 Long-term medical management of ischemic stroke and transient ischemic attack due to arterial disease 1129
Ch. 59 Carotid stenting 1151
Ch. 60 Secondary prevention of cardioembolic stroke 1171
Ch. 61 Conduct of stroke-related clinical trials 1187
Ch. 62 Familial vascular diseases of neurosurgical significance 1211
Ch. 63 Intracerebral hemorrhage 1217
Ch. 64 Intraventricular hemorrhage 1231
Ch. 65 Carotid endarterectomy 1245
Ch. 66 Asymptomatic carotid occlusive disease 1269
Ch. 67 Intracranial aneurysms 1279
Ch. 68 Vascular malformations of the brain 1337
Ch. 69 Cavernous malformations and venous anomalies : natural history and surgical management 1369
Ch. 70 Dural arteriovenous malformations 1393
Ch. 71 Moyamoya disease : surgical aspects 1405
Ch. 72 Spinal arteriovenous malformations 1417
Ch. 73 Cerebral vasospasm 1423
Ch. 74 Extracranial-intracranial bypass for cerebral ischemia 1437
Ch. 75 Cerebral infarction : surgical treatment 1447
Ch. 76 Cerebellar infarction and hemorrhage 1459
Ch. 77 Nontraumatic intracranial arterial dissection 1467
Ch. 78 Interventional neuroradiologic therapy
Ch. 79 Standards for surgical treatment of cerebrovascular disease, circa 2000 1521
Index 1547