Equine Internal Medicine is devoted solely to internal medicine. This problem-oriented book is organized into two primary sections. Part 1 focuses on the mechanisms underlying disease and the principles underlying treatment. Part 2 takes a body systems approach to common problems. Individual diseases are discussed in terms of anatomy and physiology, pathophysiology, clinical signs, diagnosis, and treatment.

• Editors and contributors are authorities in their fields.
• The book takes a problem-based approach to understanding equine internal medicine and demonstrates the importance of evidence-based medicine.
• Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.
• Body systems chapters begin with a thorough discussion of the diagnostic method appropriate to the system, including physical examination, clinical pathology, radiography, endoscopy, and ultrasonography.
• Information is current and well referenced.
• Flow charts, diagrams, and algorithms clarify and enhance complex material.

• The 2nd edition features a new editor, Debra C. Sellon, DVM.
• Two new chapters have been added: Critical Care (Chapter 6) and Epidemiology (Chapter 21).
• New content has been added to Clinical Approach to Commonly Encountered Problems (Chapter 3): changes in body temperature, diarrhea, and clinical assessment of poor performance.
• The chapters on Pharmacology (Chapter 4) and Hematopoietic System (Chapter 12) both have new authors and are totally rewritten and updated.
• The chapter on the Gastrointestinal System (Chapter 13)has new authors and new sections on examination for disorders of the gastrointestinal tract, gastrointestinal inflammation, diarrhea, malabsorption syndromes and maldigestion, and mucosal injury and repair.
• Endocrine Disorders (Chapter 18) has new authors, has been completely rewritten, and includes a new section on magnesium disorders.
• New content includes significant updates to the coverage of foal medicine, as well as the addition of a section devoted to pain management.

1 The Equine Immune System 1
1.1 Equine Immunology 1
1.2 Hypersensitivity and Autoimmunity 29
1.3 Immunodeficiency 37
1.4 Immunomodulators 52
2 Mechanisms of Infectious Disease 59
2.1 Mechanisms of Establishment and Spread of Bacterial and Fungal Infections 59
2.2 Mechanisms of Establishment and Spread of Viral Infections 74
2.3 Internal Parasite Infections 89
2.4 Rickettsial Diseases 96
3 Clinical Approach to Commonly Encountered Problems 111
3.1 Syncope and Weakness 111
3.2 Polyuria and Polydipsia 114
3.3 Edema 120
3.4 Changes in Body Weight 124
3.5 Abdominal Distention 129
3.6 Dysphagia 132
3.7 Respiratory Distress 136
3.8 Cough 142
3.9 Changes in Body Temperature 148
3.10 Diarrhea 156
3.11 Clinical Assessment of Poor Performance 163
4 Pharmacologic Principles 169
4.1 Introduction to Clinical Pharmacology 169
4.2 Antimicrobial Therapy 186
4.3 Nonsteroidal Antiinflammatory Drugs 220
4.4 Respiratory Pharmacology 228
5 Applied Nutrition 235
6 Critical Care 273
7 Disorders of the Respiratory System 289
8 Disorders of the Cardiovascular System 355
9 Diseases of the Musculoskeletal System 461
9.1 Pathophysiology and Treatment of Acute Laminitis 522
10 Disorders of the Neurologic System 533
10.1 Neurologic Examination 533
10.2 Cerebrospinal Fluid Evaluation 542
10.3 Electrodiagnostic Aids and Selected Neurologic Diseases 546
10.4 Seizures, Narcolepsy, and Cataplexy 560
10.5 Spinal Cord, Vertebral, and Intracranial Trauma 566
10.6 Vestibular Disease 579
10.7 Diseases of the Cerebellum 588
10.8 Cervical Vertebral Stenotic Myelopathy 594
10.9 Equine Degenerative Myeloencephalopathy 599
10.10 Equine Protozol Myeloencephalitis 604
10.11 Equine Herpesvirus 1 Myeloencephalopathy 617
10.12 Polyneuritis Equi 628
10.13 Togaviral Encephalitis 631
10.14 West Nile Virus Encephalitis 640
10.15 Rabies 644
10.16 Equine Motor Neuron Disease 646
10.17 Botulism 650
10.18 Equine Grass Sickness (Equine Dysautonomia) 652
10.19 Lyme Disease in Horses 656
10.20 Head Shaking 657
10.21 Verminous Encephalomyelitis 659
11 Disorders of the Skin 667
12 Disorders of the Hematopoietic System 721
13 Disorders of the Gastrointestinal System 769
13.1 Examination for Disorders of the Gastrointestinal Tract 769
13.2 Pathophysiology of Gastrointestinal Inflammation 780
13.3 Pathophysiology of Diarrhea 789
13.4 Malabsorption Syndromes and Maldigestion: Pathophysiology, Assessment, Management, and Outcome 796
13.5 Pathophysiology of Mucosal Injury and Repair 802
13.6 Gastrointestinal Ileus 815
13.7 Endotoxemia 821
13.8 Oral Diseases 846
13.9 Esophageal Diseases 855
13.10 Diseases of the Stomach 863
13.11 Duodentitis - Proximal Jejunitis (Anterior Enteritis, Proximal Enteritis) 873
13.12 Proliferative and Inflammatory Intestinal Diseases Associated With Malabsorption and Maldigestion 878
13.13 Inflammatory Diseases of the Gastrointestinal Tract Causing Diarrhea 884
13.14 Ischemic Disorders of the Intestinal Tract 913
13.15 Obstructive Disorders of the Gastrointestinal Tract 922
13.16 Neoplasia of the Alimentary Tract 937
13.17 Peritonitis 941
14 Disorders of the Liver 951
15 Equine Ophthalmology 995
16 Disorders of the Reproductive System 1025
16.1 Reproductive Anatomy and Physiology of the Nonpregnant Mare 1025
16.2 Mare Breeding Soundness Examination 1030
16.3 Mare Reproductive Pathology 1039
16.4 Endometritis and Uterine Therapy 1049
16.5 Hormonal Manipulation of the Mare 1059
16.6 Breeding Management to Optimize Pregnancy Rates 1065
16.7 Equine Embryo Transfer 1073
16.8 The Pregnant Mare 1079
16.9 Assisted Reproductive Techniques 1130
16.10 The Stallion 1135
17 Disorders of the Urinary System 1169
17.1 Anatomy and Development 1169
17.2 Renal Physiology 1184
17.3 Examination of the Urinary System 1200
17.4 Acute Renal Failure 1221
17.5 Chronic Renal Failure 1231
17.6 Urinary Tract Infections 1253
17.7 Obstructive Disease of the Urinary Tract 1259
17.8 Hematuria 1270
17.9 Polyuria and Polydipsia 1276
17.10 Renal Tubular Acidosis 1283
17.11 Neoplasia of the Urinary Tract 1287
17.12 Urinary Incontinence and Bladder Dysfunction 1290
18 Disorders of the Endocrine System 1295
18.1 Calcium Disorders 1295
18.2 Pars Intermedia Dysfunction (Equine Cushing's Disease) 1327
18.3 Thyroid Gland 1340
18.4 The Adrenal Glands 1357
18.5 Endocrine Pancreas 1362
18.6 Magnesium Disorders 1365
19 Disorders of Foals 1381
19.1 Musculoskeletal Disorders of Foals 1431
20 Toxicologic Problems 1441
21 Veterinary Epidemiology 1513
22 Recognizing and Treating Pain in Horses 1529
App. A Applied Nutrition 1543
App. B Dosages of Hormonal Preparations 1607
Index 1608